Article
New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
Current opinion in neurobiology - 1 Feb 2022
Amin Sadaf, Carling Gillian, Gan Li
Abstract excerpt
Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the frontal and temporal lobes of the brain and has a highly heterogeneous clinical representation with patients presenting with a wide range of behavioral, language, and executive dysfunctions. Etiology of FTD is complex and consists of both familial and sporadic cases. Heterozygous mutations in the GRN gene, resulting in GRN...
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