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Article

Structure, function, and mechanism of progranulin; the brain and beyond.

Journal of molecular neuroscience : MN - 1 Nov 2011

Toh Huishi, Chitramuthu Babykumari P, Bennett Hugh P J, Bateman Andrew

Abstract excerpt

Mutation of human GRN, the gene encoding the secreted glycoprotein progranulin, results in a form of frontotemporal lobar degeneration that is characterized by the presence of ubiquitinated inclusions containing phosphorylated and cleaved fragments of the transactivation response element DNA-binding protein-43. This has stimulated interest in understanding the role of progranulin in the central nervous system,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21691802
DOI: 10.1007/s12031-011-9569-4

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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