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Article

Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.

Brain : a journal of neurology - 1 Dec 2017

Chitramuthu Babykumari P, Bennett Hugh P J, Bateman Andrew

Abstract excerpt

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associated with this unique pleiotropic factor that include, but are not limited to, embryogenesis, tumorigenesis, inflammation, wound repair, neurodegeneration and lysosome...

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Share to Frontotemporal Dementia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29053785
DOI: 10.1093/brain/awx198

Genes

GRN
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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