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Article

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

21 Dec 2009

Abstract excerpt

Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes. Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive frontotemporal dementia (FTD). However, the mechanisms are unknown. To explore the role of PGRN in vivo, we generated PGRN-deficient mice. Macrophages from these mice released less interleukin-10 and more inflammatory cytokines than wild type...

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PMID: 20026663
DOI: 10.1084/jem.20091568

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