Article
Progranulin in neurodegenerative disease.
Trends in neurosciences - 1 Jul 2014
Petkau Terri L, Leavitt Blair R
Abstract excerpt
Loss-of-function mutations in the progranulin gene are a common cause of familial frontotemporal dementia (FTD). The purpose of this review is to summarize the role of progranulin in health and disease, because the field is now poised to begin examining therapeutics that alter endogenous progranulin levels. We first review the clinical and neuropathological phenotype of FTD patients carrying mutations in the...
Topics
- Animals
- Brain
- Genetic Variation
- Humans
- Intercellular Signaling Peptides and Proteins
- Mice
- Neurodegenerative Diseases
- Neurons
- Progranulins