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Article

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

8 Jun 2021

Abstract excerpt

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer's disease. PGRN is highly expressed in the microglia near Aβ plaques and influences plaque dynamics and microglial activation. However, the detailed mechanisms remain elusive. Here we report that PGRN deficiency reduces human APP and Aβ levels in the young male...

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Identifiers

PMID: 34103390
DOI: 10.26508/lsa.202000874

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