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Article

Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jan 2023

Kashyap Shreya N, Boyle Nicholas R, Roberson Erik D

Abstract excerpt

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal dementia (FTD), a leading cause of early-onset dementia characterized clinically by behavioral, social, and language deficits. There are currently no FDA-approved therapeutics for FTD-GRN, but this has been an active area of investigation, and several approaches are now in clinical trials. Here, we review preclinical development of...

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Identifiers

PMID: 36781744
DOI: 10.1007/s13311-023-01348-6
PMCID: PMC10119358

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