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Article

Potential mechanisms of progranulin-deficient FTLD.

Journal of molecular neuroscience : MN - 1 Nov 2011

Ward Michael Emmerson, Miller Bruce L

Abstract excerpt

Frontotemporal lobar dementia (FTLD) is the most common cause of dementia in patients younger than 60 years of age, and causes progressive neurodegeneration of the frontal and temporal lobes usually accompanied by devastating changes in language or behavior in affected individuals. Mutations in the progranulin (GRN) gene account for a significant fraction of familial FTLD, and in the vast majority of cases, these...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

Share to Nonsense Mediated mRNA Decay

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Source

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Identifiers

PMID: 21892758
DOI: 10.1007/s12031-011-9622-3
PMCID: PMC3767571

Genes

GRN

Provenance

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