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Recent Insights into the Involvement of Progranulin in Frontotemporal Dementia

1 Dec 2011

Abstract excerpt

Progranulin is a widely expressed protein that is involved in the regulation of multiple biological processes, including embryogenesis, host defense, and wound repair. In the central nervous system, progranulin is constitutively expressed at modest levels in neurons and microglia, but shows dramatic microglial immunoreactivity in degenerative diseases that exhibit prominent neuroinflammation. In addition to the...

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PMID: 22654721
DOI: 10.2174/157015911798376361

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