Article

Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The androgen receptor (AR) is a critical driver of prostate cancer (PCa). To study regulators of AR protein levels and oncogenic activity, we created the first live cell quantitative endogenous AR fluorescent reporters. Leveraging this novel AR reporter, we performed genome-scale CRISPRi flow cytometry sorting screens to systematically identify genes that modulate AR protein levels. We identifie...

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Literature Corpus work: f14af785-3a5d-5983-8ce8-1cfc2ead6f3e
DOI: 10.1101/2025.05.29.656244

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