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An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

29 Jul 2021

Abstract excerpt

Genomic sequencing of thousands of tumors has revealed many genes associated with specific types of cancer. Similarly, large scale CRISPR functional genomics efforts have mapped genes required for cancer cell proliferation or survival in hundreds of cell lines. Despite this, for specific disease subtypes, such as metastatic prostate cancer, there are likely a number of undiscovered tumor specific driver genes...

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PMID: 34326322
DOI: 10.1038/s41467-021-24919-7

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