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Article

SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression

20 Aug 2019

Abstract excerpt

Abstract Androgen receptor splice variant-7 (AR-V7) is a constitutively active AR variant implicated in castration-resistant prostate cancers. Here, we show that the RNA splicing factor SF3B2, identified by in silico and CRISPR/Cas9 analyses, is a critical determinant of AR-V7 expression and is correlated with aggressive cancer phenotypes. Transcriptome and PAR-CLIP analyses revealed that SF3B2 controls the...

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PMID: 31431456
DOI: 10.1158/0008-5472.can-18-3965

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