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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

2020-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) is effective in the initial treatment of prostate cancer, resistance to ADT or to next-generation androgen pathway inhibitors invariably arises, most commonly through re-activation of the AR axis. Thus, orthogonal approaches to inhibit AR signaling in advanced...

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Literature Corpus work
252a3adc-5251-5e30-a4bd-fda3ab0fd95a
DOI
10.1101/2020.06.17.156034
Open publication

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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancerDOI 10.1101/2020.06.17.156034
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