Article

CRISPR screening reveals SYCP3 as a key driver of metastasis in prostate cancer

2025-01-31

Abstract excerpt

<h4>SUMMARY</h4> Prostate cancer (PCa) is a prevalent male cancer with high survival rates, except in advanced or metastatic stages, for which effective treatments are lacking. Metastatic PCa involves complex mechanisms including loss of tumor suppressor genes and DNA repair molecules, which impacts therapy responses. We have reanalyzed data from a CRISPR/Cas9 genome wide screening previously performed to identif...

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Literature Corpus work: 63de8835-33b4-511a-9483-6ed876926612
DOI: 10.1101/2025.01.30.629925

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