Article

Enhancer RNA transcriptome-wide association study reveals an atlas of pan-cancer susceptibility eRNAs

2024-03-02

Abstract excerpt

<h4>Summary</h4> Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)- mediated genetic effects from 28,033 RNA sequencing samples across 11,606 individuals, identifying 11,757 eRNA quantitative trait loci (eRNA-QTLs) significantly associated with eRNA expression. Mechanistically, eRNA-Q...

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Literature Corpus work: 7eb3d867-042c-5ee6-9020-2b377d7f3565
DOI: 10.1101/2024.02.29.24303580

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