Article

AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancer

2026-04-27

Abstract excerpt

Treatment resistance in prostate cancer remains a major clinical challenge. While single-cell transcriptomics enables mapping of cellular composition and resistance-associated states, the gene regulatory programs driving these state transitions remain poorly defined. Here, we integrate single-cell chromatin accessibility and transcriptome sequencing data from an in vitro model to resolve the regulatory program ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b169a65-e07b-586d-98cb-702bcda0655c
DOI: 10.64898/2026.04.27.721035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AR suppression rewires a SOX4 regulatory program to promote enzalutamide resistance in prostate cancerDOI 10.64898/2026.04.27.721035Read

Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancerSemantic proximity Read

Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like CharacteristicsSemantic proximity Read

Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independenceSemantic proximity Read

SOX2 expression in prostate cancer drives resistance to nuclear hormone receptor signaling inhibition through the WEE1/CDK1 signaling axisSemantic proximity Read

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancerSemantic proximity Read

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilitiesSemantic proximity Read

An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor ProgressionSemantic proximity Read

Cellular cartography reveals mouse prostate organization and determinants of castration resistanceSemantic proximity Read

Cellular cartography reveals mouse prostate organization and determinants of castration resistanceSemantic proximity Read

Transcriptional mediators of treatment resistance in lethal prostate cancerSemantic proximity Read

Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancerSemantic proximity Read

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancerSemantic proximity Read