Article

Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate Cancer

2019-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of mRNA alternative splicing (AS) has been implicated in development and progression of hematological malignancies. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) development, progression and therapy resistance. We find that the severity of splicing dysregulation correlates with disease progression and establish intron retention...

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Literature Corpus work: 2eae9923-ff62-5743-81dc-73b2846b90ad
DOI: 10.1101/634402

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