Article

Canonical AREs are tumor suppressive regulatory elements in the prostate

2024-02-27

Abstract excerpt

The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression 1 . It is also a key driver of prostate tumorigenesis, becoming “hijacked” to drive oncogenic transcription 2-5 . However, the regulatory elements determining the execution of the growth suppressive AR transcriptional program, and whether...

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Literature Corpus work: 09ed0990-22a0-5f1f-b54b-8af10ce10eb7
DOI: 10.1101/2024.02.23.581466

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