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CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

1 Feb 2025

Abstract excerpt

Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is co-amplified with the AR gene body and contributes to increased AR transcription and resistance to androgen deprivation therapy. However, the mechanism of enhancer activation in advanced disease is unknown. Here, we...

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PMID: 39954255
DOI: 10.1016/j.celrep.2025.115312

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