Article

Defining the Limits of hPSC Derived Models: hPSC-MSNs Fail to Recapitulate Authentic Striatal Identity

2024-06-26

Abstract excerpt

Human pluripotent stem cells (hPSCs) are increasingly used to model human disease and as donor cells for regenerative medicine. However, the fidelity of hPSC-derived cell types remains a major concern, particularly when these cells are intended to replicate complex or region-specific subtypes, such as those required to explore and treat neurological diseases. Medium spiny neurons (MSNs), the principal projection n...

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Literature Corpus work: f1389021-23e2-54ac-a26f-76ffcd417336
DOI: 10.1101/2024.06.25.600518

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