Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular Models: HD Patient-Derived Pluripotent Stem Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Geater Charlene, Hernandez Sarah, Thompson Leslie, Mattis Virginia B

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded polyglutamine (polyQ)-encoding repeats in the Huntingtin (HTT) gene. Traditionally, HD cellular models consisted of either patient cells not affected by disease or rodent neurons expressing expanded polyQ repeats in HTT. As these models can be limited in their disease manifestation or proper genetic context,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cell Transdifferentiation
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Huntingtin Protein

Share to Huntington Disease

Share to Induced Pluripotent Stem Cells

Share to Precision Medicine

Source

Identifiers

PMID: 29856014
DOI: 10.1007/978-1-4939-7825-0_4

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular Models: HD Patient-Derived Pluripotent Stem Cells.PMID 29856014Read ↗

Recent Overview of the Use of iPSCs Huntington’s Disease Modeling and TherapySemantic proximity Read ↗

Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease.Semantic proximity Read ↗

<i>In vivo</i> progressive degeneration of Huntington’s disease patient-derived neurons reveals human-specific pathological phenotypesSemantic proximity Read ↗

Use of human stem cells in Huntington disease modeling and translational research.Semantic proximity Read ↗

Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in NeurotraumaSemantic proximity Read ↗

Disease-Specific iPS Cell Models in NeuroscienceSemantic proximity Read ↗

Human-induced pluripotent stem cells: potential for neurodegenerative diseases.Semantic proximity Read ↗

Advances and Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cells in Modeling Neurodegenerative DiseaseSemantic proximity Read ↗

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances and LimitationsSemantic proximity Read ↗

Reversal of cellular phenotypes in neural cells derived from Huntington's disease monkey-induced pluripotent stem cells.Semantic proximity Read ↗

Pluripotent stem cells in neurodegenerative and neurodevelopmental diseasesSemantic proximity Read ↗

Human stem cell models of neurodegeneration: a novel approach to study mechanisms of disease development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.