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Article

Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?

27 Jan 2017

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease that offers an excellent paradigm for cell replacement therapy because of the associated relatively focal cell loss in the striatum. The predominant cells lost in this condition are striatal medium spiny neurons (MSNs). Transplantation of developing MSNs taken from the fetal brain has provided proof of concept that donor MSNs can survive, integrate and...

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PMID: 28137534
DOI: 10.1016/j.neuint.2017.01.016

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