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Article

Use of human stem cells in Huntington disease modeling and translational research.

Experimental neurology - 1 Apr 2016

Golas Monika M, Sander Bjoern

Abstract excerpt

Huntington disease (HD) is a devastating neurological disorder caused by an extended CAG repeat in exon 1 of the gene that encodes the huntingtin (HTT) protein. HD pathology involves a loss of striatal medium spiny neurons (MSNs) and progressive neurodegeneration affects the striatum and other brain regions. Because HTT is involved in multiple cellular processes, the molecular mechanisms of HD pathogenesis should...

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Source

Identifiers

PMID: 26826449
DOI: 10.1016/j.expneurol.2016.01.021

Genes

HTT
MSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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