Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating DNA methylation dynamics and safety of human embryonic stem cell differentiation toward striatal neurons.

Stem cells and development - 15 Oct 2015

Baronchelli Simona, La Spada Alberto, Conforti Paola, Redaelli Serena, Dalprà Leda, De Blasio Pasquale, Cattaneo Elena, Biunno Ida

Abstract excerpt

The potential use of human embryonic stem cells (hESCs) in cell-based therapies points out the critical importance of epigenomic evaluation for cell-based therapies. Specifically, DNA methylation appears to be a crucial player in establishing cell fate commitment and lineage choices. In this study, we report the global changes observed on the CpG islands distributed in promoters, gene bodies, and intergenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corpus Striatum

Share to DNA Methylation

Share to Human Embryonic Stem Cells

Share to Neurons

Share to Phenotype

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 26132372
DOI: 10.1089/scd.2015.0057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating DNA methylation dynamics and safety of human embryonic stem cell differentiation toward striatal neurons.PMID 26132372Read ↗

Defining the Limits of hPSC Derived Models: hPSC-MSNs Fail to Recapitulate Authentic Striatal IdentitySemantic proximity Read ↗

A multi-omics approach to visualize early neuronal differentiation in 4DSemantic proximity Read ↗

Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington diseaseSemantic proximity Read ↗

Single Cell Gene Expression Analysis Reveals Human Stem Cell-Derived Graft Composition in a Cell Therapy Model of Parkinson’s DiseaseSemantic proximity Read ↗

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.Semantic proximity Read ↗

Alterations of genomic imprinting appear during the reprogramming of adult neural stem cellsSemantic proximity Read ↗

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiationSemantic proximity Read ↗

Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.Semantic proximity Read ↗

Epigenetic patterns of embryonic and adult stem cellsSemantic proximity Read ↗

Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESCSemantic proximity Read ↗

DNA methylation in stem cell renewal and multipotencySemantic proximity Read ↗

Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.