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Article

Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments

17 Nov 2022

Abstract excerpt

The striatum links neuronal circuits in the human brain, and its malfunction causes neuronal disorders such as Huntington's disease (HD). A human striatum model that recapitulates fetal striatal development is vital to decoding the pathogenesis of striatum-related neurological disorders and developing therapeutic strategies. Here, we developed a method to construct human striatal organoids (hStrOs) from human...

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PMID: 36395338
DOI: 10.1371/journal.pbio.3001868

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