Back to search

Article

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

2026-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (mDA) neurons 1 . Stem cell–derived mDA neurons hold promise for disease modelling 2,3 and are currently in clinical trials for cell replacement therapy 4–6 . However, systematic benchmarking has been limited by the lack of a unified high-resolution reference and methods that quantify incomplete or mixe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef7fdca8-7421-5417-afe8-85d0cfa2f7f1
DOI
10.64898/2026.06.19.733041
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidatesDOI 10.64898/2026.06.19.733041
BrainSTEM: A multi-resolution fetal brain atlas to assess the fidelity of human midbrain culturesSemantic proximity
Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signalingSemantic proximity
Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCsSemantic proximity
Molecular Diversity of Midbrain Development in Mouse, Human, and Stem CellsSemantic proximity
A molecular atlas of cell-type specific signatures in the parkinsonian striatumSemantic proximity
Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neuronsSemantic proximity
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s diseaseSemantic proximity
Lineage-selective suicide gene system enables post-engraftment editing of cell therapy compositionSemantic proximity
Induction of Dopaminergic Neurons for Neuronal Subtype-Specific Modeling of Psychiatric Disease RiskSemantic proximity
Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiationSemantic proximity
Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiationSemantic proximity
Reconstitution of Human Brain Cell Diversity in Organoids via Four ProtocolsSemantic proximity
Select a neighboring publication to make it the new centre.