Back to search

Article

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

2024-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Base editors create precise genomic edits by directing nucleobase deamination or removal without inducing double-stranded DNA breaks. However, a vast chemical space of other DNA modifications remains to be explored for genome editing. Here, we harness the bacterial anti-phage toxin DarT2 to append ADP-ribosyl moieties to DNA, unlocking distinct editing outcomes in bacteria versus eukaryotes. Fus...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f133d9eb-1eca-513f-8a6d-56a78c20fd7a
DOI
10.1101/2024.11.17.623984
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotesDOI 10.1101/2024.11.17.623984
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotesSemantic proximity
Unlocking the secrets of ABEs: the molecular mechanism behind their specificity.Semantic proximity
Genome Editing With Targeted DeaminasesSemantic proximity
Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase.Semantic proximity
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.Semantic proximity
A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility.Semantic proximity
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.Semantic proximity
Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors.Semantic proximity
Editing the Genome Without Double-Stranded DNA BreaksSemantic proximity
Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminasesSemantic proximity
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNASemantic proximity
High-efficiency base editing for nuclear and mitochondrial DNA with an optimized DYW-like deaminaseSemantic proximity
Select a neighboring publication to make it the new centre.