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Article

Unlocking the secrets of ABEs: the molecular mechanism behind their specificity.

Biochemical Society transactions - 31 Aug 2023

Chen Xiaoyu, McAndrew Mitchell J, Lapinaite Audrone

Abstract excerpt

CRISPR-Cas, the bacterial immune systems, have transformed the field of genome editing by providing efficient, easily programmable, and accessible tools for targeted genome editing. DNA base editors (BE) are state-of-the-art CRISPR-based technology, allowing for targeted modifications of individual nucleobases within the genome. Among the BEs, adenine base editors (ABEs) have shown great potential due to their...

Topics

CRISPR-Cas Systems
Adenine
Gene Editing
Mutation
Genome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37526140
DOI: 10.1042/BST20221508
PMCID: PMC10586758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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