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Article

Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase.

Nature communications - 30 Jul 2024

Yi Zongyi, Zhang Xiaoxue, Wei Xiaoxu, Li Jiayi, Ren Jiwu, Zhang Xue, Zhang Yike, Tang Huixian, Chang Xiwen, Yu Ying, Wei Wensheng

Abstract excerpt

DNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA synthesis pathway through the engineering of uracil-DNA glycosylase (UNG). Employing structure-based rational design, exploration of homologous proteins, and...

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Source

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Identifiers

PMID: 39080265
DOI: 10.1038/s41467-024-50012-w
PMCID: PMC11289083

Genes

UNG
IDUA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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