Article

Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cells

2024-05-18

Abstract excerpt

Arrest of elongating RNA polymerase II (RNAPII) at DNA lesions initiates transcription-coupled repair (TCR), involving the concerted action of specific TCR factors, followed by downstream nucleotide excision repair steps. Remarkedly, only congenital defects in the CSA or CSB genes cause the neurodegenerative disorder Cockayne syndrome, which is not observed with other TCR genes, despite their equal importance in T...

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Literature Corpus work: f12763c7-dd53-5a74-9ca7-257dd636df8b
DOI: 10.1101/2024.05.17.594644

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