Article
TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.
Nature communications - 12 Mar 2018
Pines Alex, Dijk Madelon, Makowski Matthew, Meulenbroek Elisabeth M, Vrouwe Mischa G, van der Weegen Yana, Baltissen Marijke, French Pim J, van Royen Martin E, Luijsterburg Martijn S, Mullenders Leon H, Vermeulen Michiel, Vermeulen Wim, Pannu Navraj S, van Attikum Haico
Abstract excerpt
Transcription-blocking DNA lesions are removed by transcription-coupled nucleotide excision repair (TC-NER) to preserve cell viability. TC-NER is triggered by the stalling of RNA polymerase II at DNA lesions, leading to the recruitment of TC-NER-specific factors such as the CSA-DDB1-CUL4A-RBX1 cullin-RING ubiquitin ligase complex (CRLCSA). Despite its vital role in TC-NER, little is known about the regulation of...
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