Article

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesions

2024-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (PolII), which then initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery. In the absence of TCR, eviction of lesion-stalled PolII is required for alternative pathways to address the damage, but the mechanism is unclear. This study, utilizing Protein-Associated DNA Damage Sequencing (P...

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Literature Corpus work: 864e7335-b11a-5bac-8380-1fe9e6952e2a
DOI: 10.1101/2024.07.07.602436

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