Article
DNA damage response and transcription.
DNA repair - 15 Jul 2011
Lagerwerf Saskia, Vrouwe Mischa G, Overmeer René M, Fousteri Maria I, Mullenders Leon H F
Abstract excerpt
A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and the initiation of a signal transduction cascade that activates genome-protection pathways including nucleotide excision repair (NER). NER operates through coordinated assembly of repair factors into pre- and post-incision complexes. Recent work identifies RPA as a key regulator of the transition from dual incision to...
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