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The emerging role of Cockayne group A and B proteins in ubiquitin/proteasome-directed protein degradation.

Mechanisms of ageing and development - 1 Apr 2021

Paccosi Elena, Proietti-De-Santis Luca

Abstract excerpt

When mutated, csa and csb genes are responsible of the complex phenotype of the premature aging Cockayne Syndrome (CS). Our working hypothesis is to reconcile the multiple cellular and molecular phenotypes associated to CS within the unifying molecular function of CSA and CSB proteins in the cascade of events leading to ubiquitin/proteasome-directed protein degradation, which occurs in processes as DNA repair,...

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Identifiers

PMID: 33727156
DOI: 10.1016/j.mad.2021.111466

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