Article
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Molecular cell - 28 Oct 2005
Sarker Altaf H, Tsutakawa Susan E, Kostek Seth, Ng Cliff, Shin David S, Peris Marian, Campeau Eric, Tainer John A, Nogales Eva, Cooper Priscilla K
Abstract excerpt
Loss of a nonenzymatic function of XPG results in defective transcription-coupled repair (TCR), Cockayne syndrome (CS), and early death, but the molecular basis for these phenotypes is unknown. Mutation of CSB, CSA, or the TFIIH helicases XPB and XPD can also cause defective TCR and CS. We show t...
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