Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription-coupled repair of DNA–protein crosslinks

30 Nov 2024

Abstract excerpt

DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple human diseases. They are caused by various endogenous and environmental agents, and from the actions of enzymes such as topoisomerases. DPCs impede DNA polymerases, triggering replication-coupled DPC repair. Until recently the consequences of DPC blockade of RNA polymerases remained unclear. New methodologies for studying DPC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39617652
DOI: 10.1016/j.tcb.2024.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription-coupled repair of DNA–protein crosslinksPMID 39617652Read ↗

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.Semantic proximity Read ↗

RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cellsSemantic proximity Read ↗

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repairSemantic proximity Read ↗

DNA damage response and transcription.Semantic proximity Read ↗

ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer TherapySemantic proximity Read ↗

Chemistry and Biology of DNA RepairSemantic proximity Read ↗

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks <i>in vivo</i>Semantic proximity Read ↗

DNA replication stress: from molecular mechanisms to human diseaseSemantic proximity Read ↗

Disorders of nucleotide excision repair.Semantic proximity Read ↗

Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair.Semantic proximity Read ↗

Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.Semantic proximity Read ↗

Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.