Article
Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.
Nucleic acids research - 6 Sept 2018
Boetefuer Erica L, Lake Robert J, Fan Hua-Ying
Abstract excerpt
Cockayne syndrome protein B (CSB) is a member of the SNF2/SWI2 ATPase family and is essential for transcription-coupled nucleotide excision DNA repair (TC-NER). CSB also plays critical roles in transcription regulation. CSB can hydrolyze ATP in a DNA-dependent manner, alter protein-DNA contacts and anneal DNA strands. How the different biochemical activities of CSB are utilized in these cellular processes have...
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