Article

Prolonged stalling of RNA Polymerase II at DNA damage explains phenotypical differences between Cockayne and UV-sensitive syndromes

2023-05-18

Abstract excerpt

Faithful transcription of eukaryotic genes by RNA polymerase II (Pol II) is essential for proper cell function. Nevertheless, the integrity of the DNA template of Pol II is continuously challenged by different sources of DNA damage, such as UV-light, that impede transcription. When unresolved, these transcription-blocking lesions (TBLs) can cause cellular dysfunction, senescence and apoptosis, eventually resulting...

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Literature Corpus work: 67b8ad59-6514-5c44-a438-ce59b77b1c2c
DOI: 10.1101/2023.05.17.541110

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