Article

Development of an AchillesTAG degradation system and its application to control CAR-T activity

2021-01-01

Abstract excerpt

In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chemical biology tools to interrogate complex biology. TPD offers an all-chemical strategy capable of the potent, durable, selective, reversible, and time-resolved control of the levels of a given target protein in both in vitro and in vivo contex...

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Literature Corpus work: c1da2c5b-41d0-5337-971a-78fba6231aa1
DOI: 10.1016/j.crchbi.2021.100010

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