Article

Precise Control of Switchable Chimeric Antigen Receptor T Cells Allows Enhanced Safety and Less T Cell Exhaustion

2025-12-10

Abstract excerpt

<h4>Background</h4> Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success in hematologic malignancies, yet their clinical utility remains limited by safety concerns, limited persistence, and T-cell exhaustion driven by continuous receptor signaling. While switchable CAR designs provide external control, many reported systems are irreversible, strictly binary, or compromise CAR-T potenc...

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Literature Corpus work: 939a1207-bd69-5067-9c20-b67747601ce8
DOI: 10.64898/2025.12.07.692875

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