Article

Drug-Mediated Control of Receptor Valency Enhances Immune Cell Potency

2023-01-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Design: </h4> er T cells offer a novel paradigm for treating diseases like cancer, yet they are often hindered by target recognition evasion and limited in vivo control. To overcome these challenges, we develop valency-controlled receptors (VCRs), a novel class of synthetic receptors engineered to enable precise modulation of immune cell activity. VCRs use custom-designed valency-control lig...

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Literature Corpus work: a6a72003-955d-5367-acae-80935d090513
DOI: 10.1101/2023.01.04.522664

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