Synthetic Hybrid Receptors for Safer and Programmable T Cell Therapy

Abstract excerpt

Engineered T cell therapies have achieved significant clinical success in hematological malignancies but remain largely ineffective in solid tumors. Overcoming this limitation requires strategies that enhance T cell function while avoiding systemic immune toxicities and pathological T cell states. Existing approaches typically rely on constitutive gene overexpression or suppression to augment potency or remodel th...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Nanowire Synthesis and Applications
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

a21fcf18-e47c-50b8-96f5-7f485b1983dd

DOI

10.64898/2026.01.22.701150