Article

Degron-based bioPROTACs for controlling signaling in CAR T cells

2024-02-17

Abstract excerpt

Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but potent signaling through the CAR can be detrimental to treatment safety and efficacy. The use of protein degradation to control CAR signaling can address these issues in pre-clinical models. Existing strategies for regulating CAR stability rely on small molecules to induce systemic degradation. In contrast to small molecule re...

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Literature Corpus work: 216bbfcd-fd73-571b-81c4-be3e904f2b7b
DOI: 10.1101/2024.02.16.580396

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