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Article

Safety switches for adoptive cell therapy

10 Aug 2021

Abstract excerpt

Adoptive transfer of allogeneic and genetically modified T cells, such as CAR-T and TCR-T cells, can induce profound immune reactivity against cancer tissue. At the same time, these therapies are associated with severe off-target and on-target toxicities. For this reason, the development of genetic safety switches that can be used to control the activity of T cells in vivo has become an active field of research....

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PMID: 34389174
DOI: 10.1016/j.coi.2021.07.002

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