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T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors

8 Oct 2020

Abstract excerpt

The impressive success of chimeric antigen receptor (CAR)-T cell therapies in treating advanced B-cell malignancies has spurred a frenzy of activity aimed at developing CAR-T therapies for other cancers, particularly solid tumors, and optimizing engineered T cells for maximum clinical benefit in many different disease contexts. A rapidly growing body of design work is examining every modular component of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33050044
DOI: 10.3390/ijms21197424

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