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Cancer Selective Target Degradation by Folate-Caged PROTACs

10 May 2021

Abstract excerpt

PROTACs (proteolysis targeting chimeras) are an emerging class of promising therapeutic modalities that degrade intracellular protein targets by hijacking the cellular ubiquitin-proteasome system. However, potential toxicity of PROTACs in normal cells due to the off-tissue on-target degradation effect limits their clinical applications. Precise control of a PROTAC's on-target degradation activity in a...

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PMID: 33970635
DOI: 10.1021/jacs.1c00451

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