Engineering human protein switches for functional control of CARs and transcription factors via oral drug administration

Abstract excerpt

While CAR T cells have revolutionized the treatment of certain hematologic malignancies, they can cause severe toxicities, which are expected to be exacerbated with next-generation CAR Ts engineered for improved proliferation, persistence, and efficacy. Therefore, regulatory systems are urgently needed to be able to control these living drugs directly in patients. Here, we engineered a molecular switch, in which t...

Topics

Open a Topic to create a Post that cites this publication.

• Biosimilars and Bioanalytical Methods
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Nanowire Synthesis and Applications
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

f4556cf7-c4a7-59bc-b2d5-252e3beec935

DOI

10.1101/2025.10.17.683068