Article

Amount of Pannexin 1 in smooth muscle cells regulates sympathetic nerve induced vasoconstriction

2022-09-09

Abstract excerpt

Pannexin 1 (Panx1) forms high conductance channels that secrete ATP upon stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic nerve stimulation is not known. Additionally, it is unknown how the expression level of Panx1 in SMCs influences a-adrenergic responses. We hypothesized that the amount of Panx1 in SMCs dictates the levels of sympathetic constriction and blood pressure....

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Literature Corpus work: f0eedcd8-9d1a-50d8-930b-0e01466184fe
DOI: 10.1101/2022.09.07.506995

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