Article

Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner

2025-02-08

Abstract excerpt

Ischemic stroke is a leading cause of morbidity and mortality. We have previously shown that deletion of endothelial cell (EC) Panx1 reduces ischemic stroke infarct volume and reduces cerebral arterial myogenic reactivity, which regulates cerebral blood flow. We hypothesized that EC Panx1 content dictates ischemic stroke outcome and thus increased EC Panx1 expression will worsen ischemic stroke outcomes due to exa...

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Literature Corpus work: 4bd0bb62-0d74-54d7-94bd-0b6a6607a632
DOI: 10.1101/2025.02.07.636909

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