Article

Differential activation of mouse and human Panx1 channel variants

2023-10-12

Abstract excerpt

Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1), the most thoroughly characterized isoform of this family, forms plasmalemmal membrane channels permeable to relatively large molecules, such as ATP. Although human and mouse Panx1 amino acid sequences are conserved in the presently known regulatory sites involved in trafficking and modulation of the channel, differences are report...

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Literature Corpus work: 730ad58d-e160-509d-92ff-20f878f6c5c9
DOI: 10.1101/2023.10.11.561880

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